WHITE PAPER Validation of a deformable atlas-based left ventricular segmentation method for PET and SPECT: comparison to cardiac computed tomography angiography (CCTA) volumes

Gated myocardial perfusion SPECT and PET are commonly used to calculate left ventricular ejection fraction (LVEF) and assess left ventricular end diastolic (EDV) and end systolic volumes (ESV). A number of software methods have been developed to automatically calculate these parameters. In a previous work we compared the LV parameters (EF, EDV, ESV) for three software packages: MIMcardiac®, QGS, and 4D-MSPECT for gated myocardial perfusion SPECT. This work demonstrated the methods correlated well but were still significantly different. The various software packages utilize different methods for LV segmentation therefore understanding the accuracy of each method is essential. Our goal in the current work is to evaluate the left ventricular volumes calculated by MIMcardiac (MIM Software Inc) for gated myocardial perfusion PET and SPECT using CCTA as the reference standard.